Skp2

Item no.	10-786-259097
Manufacturer	GENWAY
Amount	0.01 mg
Category	Peptides & Proteins Recombinant Proteins Western Blot ELISA
Type	Proteins
Applications	WB, ELISA
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-6B3D11
Similar products	10-786-259097
Available
Genway ID:	GWB-6B3D11
Amino Sequence:	aa 221-425
Activity:	Not known
Characterization:	On SDS-PAGE commassie blue stained gel the purified recombinant protein shows a band at 49kDa (including GST). SKP2 is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression signal transduction and transcription. SKP2 specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. This gene is established as a protooncogene causally involved in the pathogenesis of lymphomas (referenced from swissprot).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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