CD71

CD71

Phosphate buffered saline

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand the heditary hemochromatosis protein HFE competes for binding with transferrin for an overlapping C-terminal binding site.

Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Regulated by cellular iron levels through binding of the iron regulatory proteins IRP1 and IRP2 to iron-responsive elements in the 3\' -UTR. Up-regulated upon mitogenic stimulation.

Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).

Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis pregnancy irritable bowel syndrome and in HIV patients.

Belongs to the peptidase M28 family. M28B subfamily [view classification].