Anti-Telomerase Associated Protein 1 (TEP1)

GWB-275867

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human telomerase associated protein 1 (TEP1). Family: Transcription Factor Fraction: Affinity Purified

ELISA 1:10 000 - 1:40 000WESTERN BLOT 1 -2 ?g/mlIF MICROSCOPY User OptimizedOTHER APPLICATIONS User OptimizedPhysical State: Liquid (sterile filtered)Purity and

1. 0 mg/ml (by UV absorbance at 280 nm)

Dry Ice Telomerase is an RNA-dependent DNApolymerase that uses an RNA component to add telomericrepeat sequences at the ends of chromosomes. Besides theRNA component which serves as the template that specifiesthe telomeric repeat the telomerase complex contains areverse transcriptase protein (TRT) and various accessoryproteins including the telomerase-associated protein 1(TP1). Telomerase activity is low in most somatic cells causing the gradual shortening of telomeres which canultimately lead to telomere fusion and cell death. High levelsof telomerase activity are widely seen in cancerous cells andwhile recent experiments have suggested that telomerasemay be a viable target in cancer therapy expression levelsof TP1 do not correlate with malignancy. At least twoisoforms of TP1 are known to exist. Greider CW. Telomere length regulation. Annu. Rev. Biochem. 1996; 274:92-7. Cong YS Wright WE and Shay JW. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev. 2002; 66:407-25. Harrington L McPhail T Mar V et al. A mammalian telomerase-associated protein. Science 1997; 275:973-7. Wong JMY and Collins K. Telomere maintenance and disease. Lancet 2003; 362:983-8. Cunningham AP Love WK Zhang RW et al. Telomerase inhibition in cancer therapeutics: molecular-based approaches. Curr. Med. Chem. 2006; 13:2875-88. Hu S Chan HL Chen MC et al. Telomerase expression in benign and malignant skin neoplasms: comparison of three major subunits. J. Formos. Med. Assoc. 2002; 101:593-7.