DKK3 Antibody (N-term)

Crown Antibodies; Primary Antibodies; Cancer; Signal Transduction; SARS-Human interaction partners

DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 1 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 5 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.

RB2544

Purified Rabbit Polyclonal Antibody (Pab)

38390

15-45

WB: 1:1000
IHC-P: 1:50~100
IHC-P: 1:50~100