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SMURF2 Antibody (C-term)

SMURF2 Antibody (C-term)

Item no.	ABC-AP2105b
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Cell Biology Cell Status Immunohistochemistry Western Blot Immunofluorescence Senescence Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IF, IHC-P
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	Tajima, Y., et al., J. Biol. Chem. 278(12):10716-10721 (2003). Suzuki, C., et al., J. Biol. Chem. 277(42):39919-39925 (2002). Ebisawa, T., et al., J. Biol. Chem. 276(16):12477-12480 (2001). Zhu, H., et al., Nature 400(6745):687-693 (1999). Lambris, J., et al., J. Immunol. Methods 27(1):55-59 (1979).
NCBI	NP_073576.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	E3 ubiquitin-protein ligase SMURF2,hSMURF2,632-,SMAD ubiquitination regulatory factor 2,SMAD-specific E3 ubiquitin-protein ligase 2,SMURF2
Similar products	SMURF2, E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, hSMURF2, 632-
Available
Manufacturer - Category	Primary Antibodies; Signal Transduction; SARS-Human interaction partners
Manufacturer - Targets	This SMURF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 702-731 amino acids from the C-terminal region of human SMURF2.
Bio Background	SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB4107/4108
Gene Name	SMURF2
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, Rat
Predicted Reactivity	M, X
Calculated Molecular Weight	86196
Antigen Source	HUMAN
Antigen Region	702-731
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Dilution	IF: 1:10~50 IF: 1:10~50 WB: 1:2000 IHC-P: 1:50~100
Antigen Type	Synthetic Peptide

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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