Phospho-MAP2(S1539) Antibody

Primary Antibodies; Antibody Collections; Neuroscience; Signal Transduction; Phospho Antibodies

MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 28 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 7 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 1 and 2, MAP2a appears. At the same time, the level of MAP2c drops by 1-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.

RB15202

Purified Rabbit Polyclonal Antibody (Pab)

M, Rat

HUMAN

DB: 1:500