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ABCB11 Antibody (C-term)

ABCB11 Antibody (C-term)

Item no.	ABC-AP6110A
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ABCB11, BSEP, Bile salt export pump, ATP-binding cassette sub-family B member 11
Available
Primary Accession	O95342
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
Bio References	Chen, H.L., et al., J. Pediatr. 140(1):119-124 (2002). Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002). Strautnieks, S.S., et al., Nat. Genet. 20(3):233-238 (1998).
Clonality	Polyclonal
Clone/Animal Names	RB2211
Gene ID	8647
Gene Name	ABCB11 (HGNC:42)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	The anti-ABCB11 C-term Pab (Cat. #AP6110a) is used in Western blot to detect ABCB11 in mouse liver tissue lysate.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	146407
Antigen Region	1038-1067
Antigen Source	HUMAN
Target/Specificity	This ABCB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human ABCB11.
NCBI Accession	NP_003733.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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