VHL Antibody (C-term)

Crown Antibodies; Primary Antibodies; Cancer; Cell Biology; Metabolism

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.

RB18668

Purified Rabbit Polyclonal Antibody (Pab)

24153

181-210

WB: 1:1000
WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50