CDK8 Antibody (N-term)

Synthetic Peptide

CDK8 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery.

Polyclonal

1024

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of CDK8 antibody (N-term) (Cat.# AP7524a) in Jurkat cell line lysates (35ug/lane). CDK8 (arrow) was detected using the purified Pab.

1:1000

M

53284

HUMAN

NP_001251.1