FGFR3 Antibody (C-term)

Synthetic Peptide

FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.

Polyclonal

2261

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of anti-FGFR3 Pab (Cat. #AP7638a) in Jurkat cell lysate. FGFR3 (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

1:1000

IHC-P

Rabbit Ig

776-806

This FGFR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 776-806 amino acids from the C-terminal region of human FGFR3.