BTK Antibody (Center)

Primary Antibodies; Immunology; Signal Transduction; Catalog Updated; Anti-Kinome Antibodies; Immunity; Innate immunity; B cell receptor signaling

BTK plays a crucial role in B-cell ontogeny. This protein transiently phosphorylates GTF2I on tyrosine residues in response to B-cell receptor cross-linking. Defects in BTK are the cause of X-linked agammaglobulinemia type 1 (XLA). XLA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections like otitis, conjunctivitis, dermatitis, sinusitis or fatal sepsis or meningitis within the first years of life.

RB03117

Purified Rabbit Polyclonal Antibody (Pab)

76281

209-239

IF: 1:10~50
WB: 1:1000
IHC-P: 1:50~100