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ACVRL1 Antibody (C-term)

ACVRL1 Antibody (C-term)

Item no.	ABC-AP7807b
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applications	WB, FC, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ACVRL1, TGF-B superfamily receptor type I, ACVRLK1, ALK1, Serine/threonine-protein kinase receptor R3, Activin receptor-like kinase 1, ALK-1, SKR3, TSR-I
Available
Primary Accession	P37023
Antigen Type	Synthetic Peptide
Application	IHC-P, FC, WB
Bio Background	ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Bio References	Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Berg, J.N., et al., Am. J. Hum. Genet. 61(1):60-67 (1997). Johnson, D.W., et al., Nat. Genet. 13(2):189-195 (1996). ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993). Attisano, L., et al., Cell 75(4):671-680 (1993).
Clonality	Polyclonal
Clone/Animal Names	RB03737
Gene ID	94
Gene Name	ACVRL1
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of hACVRL1-L489 (Cat.#AP7807b) in Jurkat(lane 1), HepG2(lane 2) cell line lysates (35ug/lane). ACVRL1 (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	ACVRL1 Antibody (C-term) (Cat.#AP7807b) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Isotype	Rabbit Ig
Calculated MW	56124
Antigen Region	474-503
Antigen Source	HUMAN
Target/Specificity	This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-503 amino acids from the C-terminal region of human ACVRL1.
NCBI Accession	NP_000011.2; NP_001070869.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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