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RAF1 Antibody (S339)

RAF1 Antibody (S339)

Item no.	ABC-AP7816k
Manufacturer	Abcepta
Amount	400 ul
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot Astrocytoma
Type	Antibody Polyclonal
Applications	WB, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Citations	Chong, H., et al., J. Biol. Chem. 278(38):36269-36276 (2003). Lee, M., et al., Cancer Lett. 193(1):57-64 (2003). Alavi, A., et al., Science 301(5629):94-96 (2003). Fringer, J., et al., J. Biol. Chem. 278(23):20612-20617 (2003). Oehrl, W., et al., J. Biol. Chem. 278(20):17819-17826 (2003).
NCBI	NP_002871.1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	RAF proto-oncogene serine/threonine-protein kinase,Proto-oncogene c-RAF,cRaf,Raf-1,RAF1,RAF
Available
Manufacturer - Category	Primary Antibodies; Cancer; Cell Biology; Metabolism; Signal Transduction
Manufacturer - Targets	This RAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S339 of human RAF1.
Bio Background	RAF1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, RAF1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Clonality	Polyclonal
Polyclonal Antibody Additonal Information	RB11340
Gene Name	RAF1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Predicted Reactivity	B, C, M, Rat
Calculated Molecular Weight	73052
Antigen Source	HUMAN
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Dilution	IHC-P: 1:10~50

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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