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GSK3 beta (GSK3B) Antibody (N-term)

GSK3 beta (GSK3B) Antibody (N-term)

Item no.	ABC-AP8121a
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	GSK3B, Glycogen synthase kinase-3 beta, Serine/threonine-protein kinase GSK3B, GSK-3 beta
Available
Primary Accession	P49841
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	GSK3B, a member of the Ser/Thr protein kinase family, participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. GSK3B phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. The protein is inhibited when phosphorylated by AKT1 or ILK1. Expressed is detected in testis, thymus, prostate and ovary, and weakly in lung, brain and kidney.
Bio References	Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). Dajani, R., et al., Cell 105(6):721-732 (2001). Lau, K.F., et al., Genomics 60(2):121-128 (1999). Rhoads, A.R., et al., Mol. Psychiatry 4(5):437-442 (1999). Delcommenne, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95(19):11211-11216 (1998).
Clonality	Polyclonal
Clone/Animal Names	RB03816
Gene ID	2932
Gene Name	GSK3B
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	The anti-GSK3B Pab (Cat. #AP8121a) is used in Western blot to detect GSK3B in 293 cell lysate.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Other Accession	P18266; Q9WV60
Predicted	M, Rat
Isotype	Rabbit Ig
Calculated MW	46744
Antigen Region	4-34
Antigen Source	HUMAN
Target/Specificity	This GSK3 beta (GSK3B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-34 amino acids from the N-terminal region of human GSK3 beta (GSK3B).
NCBI Accession	NP_001139628.1; NP_002084.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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