FAS Antibody (Center)

Synthetic Peptide

FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.

Polyclonal

355

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Confocal immunofluorescent analysis of FAS Antibody (Center)(Cat#AP8530c) with T47D cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).

1:10~50

WB

Western blot analysis of FAS (arrow) using rabbit polyclonal FAS Antibody (Center) (Cat. #AP8530c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FAS gene.

1:1000

37732

HUMAN

NP_000034.1; NP_690610.1; NP_690611.1