FAS Antibody (Center)

Primary Antibodies; Cancer; Cell Biology; Immunology; Signal Transduction; Apoptosis; Apoptosis signaling; Allograft rejection

FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 1. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.

RB21902

Affinity Purified Rabbit Polyclonal Antibody (Pab)

37732

185-211

IF: 1:10~50
WB: 1:1000
WB: 1:1000