« Back
Home /
Org 274179-0

Org 274179-0

Item no.	HY-153213
Manufacturer	MedChem Express
CASRN	1421683-12-6
Amount	1 ea
Specific against	other
Citations	[1]Koppen CJ, et, al. Mechanism of action of a nanomolar potent, allosteric antagonist of the thyroid-stimulating hormone receptor. Br J Pharmacol. 2012 Apr;165(7):2314-24.
Smiles	C[C@]1(C2=CC=CC=C2)C3=CC(NC(CCC4=CC(C(F)(F)F)=CC=C4)=O)=CC=C3N(CC1)C(C)=O
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	TSH Receptor
Shipping Temperature	Room temperature
Molecular Weight	480.52
Product Description	Org 274179-0 is a potent and allosteric antagonist of thyroid-stimulating hormone (TSH) receptor, with an IC 50 of nanomolar concentration. Org 274179-0 completely inhibits TSH (and TSI)-mediated TSH receptor activation with little effect on the potency of TSH. Org 274179-0 can be used for the research of Graves' disease (GD) [1] .
Manufacturer - Research Area	Metabolic Disease
Manufacturer - Pathway	GPCR/G Protein
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 1 ea

available

Request delivery time