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Mavatrep-d6

Mavatrep-d6

Item no.	HY-16935S
Manufacturer	MedChem Express
Amount	1 ea
Specific against	other
Citations	[1]William H. Parsons, et al. Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). J. Med. Chem. 2015, 58, 9, 3859-3874.
Smiles	OC(C([2H])([2H])[2H])(C1=CC=CC=C1C2=CC=C3N=C(NC3=C2)/C=C/C4=CC=C(C=C4)C(F)(F)F)C([2H])([2H])[2H]
Alias	JNJ-39439335-d6
Shipping condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Isotope-Labeled Compounds; TRP Channel
Shipping Temperature	Room temperature
Molecular Weight	428.48
Product Description	Mavatrep-d 6 (JNJ-39439335-d 6 ) is a deuterated labeled Mavatrep (HY-16935). Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (K i =6.5 nM). Mavatrep antagonizes capsaicin-induced Ca 2+ influx with an IC 50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain [1] .
Manufacturer - Research Area	Neurological Disease
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Clinical information	No Development Reported

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