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RdRP-IN-9

RdRP-IN-9

Item no.	HY-170649
Manufacturer	MedChem Express
CASRN	1101848-34-3
Amount	1 ea
Specific against	other
Citations	[1]Mei Y, et al. Lycorine esters exert anti-HCoV-OC43 effect through reversibly acylating cysteine residue in the nsp 12 NiRAN domain[J]. Bioorganic Chemistry, 2024: 108086.
Smiles	[H][C@@]12[C@](C3=C[C@H](O)[C@H]2OC(CC)=O)([H])N(CC3)CC4=CC5=C(OCO5)C=C41
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	SARS-CoV
Shipping Temperature	Room temperature
Molecular Weight	343.37
Product Description	RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp. RdRP-IN-9 demonstrates high anti-coronavirus activity, with an EC50 value of 0.68 μM against HCoV-OC43 RdRP-IN-9 exerts a more prolonged antiviral effect by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12) and exhibits synergistic anti-coronavirus activity with Molnupiravir (HY-135853) [1].
Manufacturer - Research Area	Infection
Manufacturer - Pathway	Anti-infection
Clinical information	No Development Reported

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