« Back
Home /
Buthionine sulfoximine (BSO)

Buthionine sulfoximine (BSO)

Item no.	AGSC-B-1081-10g
Manufacturer	AG Scientific
CASRN	83730-53-4
Amount	10 g
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Format	Solid
Specific against	other
InCHI	1S/ C8H18N2O3S/ c1-2-3-5-14(10,13)6-4-7(9)8(11)12/ h7,10H,2-6,9H2,1H3,(H,11,12)/ t7-,14?/ m0/ s1
Smiles	CCCCS(=N)(=O)CC[C@@H](C(=O)O)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	83730-53-4
Available
Storage Conditions	-20°C
ChemACX	X1014401-7
Chemical Name	(2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Description	Buthionine sulfoximine (BSO) is a sulfoximine which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer. The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the first step of glutathione synthesis. Studies show methylglyoxal (MG) activated caspase-3 is enhanced in the presence of BSO. It has been reported that BSO can augment HIV-1 activation through class I HDACIs, and that it can sensitize human breast cancer cells that are anti-hormone resistant to estrogen-induced apoptosis. Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.
MDL Number	MFCD00067000
Melting Point	210 - 213°C (dec.)
Solubility	Soluble in water (> 25 mg/mL), aqueous acid, and 1N HCl.
Boiling Point	382.31 °C at 760 mmHg
Format	White Solid

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10 g

available

Delivery expected until 9/25/2025

Express Delivery: Save 21 days

Compare

Add to wishlist

Get an offer