E-64, 25 MG

X1036521-8

E-64 is an Irreversible, potent and highly selective inhibitor of cysteineproteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of theactive cysteine. E-64 will not inhibit serineproteases (except trypsin) inhibits activation-induced programmed cell death and restores defective immune responses in HIV. Specific active site titrant. E-64 inhibits calpain, papain, and cathespin B, cathepsin L.The compound has been reported to inhibit intracellular Bax protease activity, and reduce oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP activity. E-64 has also been used to study excystation in Giardia lamblia . E-64 reduces inflammation in cystic fibrosis patients. E-64 plays a role instabilizing the cytoskeleton protein Synaptopodin (Synpo), as well as, steadying signal transducer and activator of transcription-3 (STAT3). This paper points towardthe potential use of STAT3 inhibitors in therapy of glomerular diseases.

15 mg/ml in 1:1 mixture water/ethanol