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Puromycin Dihydrochloride, 25 MG

Puromycin Dihydrochloride, 25 MG

Item no.	AGSC-P-1033-25mg
Manufacturer	AG Scientific
CASRN	58-58-2
Amount	25 MG
Category	Oncology Neuroscience Neural Mitochondrial Function Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	>98% by HPLC
InCHI	1S/ C22H29N7O5/ c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/ h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/ t14-,15+,16+,18+,22+/ m0/ s1
Smiles	CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	58-58-2
Available
Storage Conditions	-20°C
ChemACX	X1001900-0
Chemical Name	(S) 3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N, N-dimethyladenosine, 3'-(a-Amino-p-methoxy-hydocinnamamido)-3'-dexoy-N, N-dimethyladenosine.2HCl
Description	Puromycin is a protein inhibitor by inhibiting translation.It is toxic to both procaryotic & eukaryotic cells.Puromycin's main function is used in cell biology as a selective antibiotic agent in cell culture systemsfor selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase (PAC). Puromycin’ slongstanding application as a gene selection antibiotic, has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system 1, 2. http://mbio.asm.org/content/6/4/e00861-15.full.pdf+html Listed below are a few published articles demonstrating the use of our Puromycin. Inquire for a full list of references. The Aryl Hydrocarbon Receptor Binds to E2F1 and Inhibits E2F1-induced Apoptosis , Jennifer L. Marlowe, Yunxia Fan, et al , Aug 2008; 19: 3263 - 3271. High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia , Marco Herling, Kaushali A. Patel, et al , Sep 2008; 111:328-337 CBP and p300 are cyto plasmic E4 polyubiquitin ligases for p53 , Dingding Shi, Marius S. Pop, et al , Sep 2009; vol. 106 no. 38:16275-16280 Related Sources 9 tips Influencing successful puromycin gene transfection Puromycin FAQs Puromycin-Antitumor Effect and Activity Puromycin; Somatic Cell Cloning
MDL Number	MFCD00866328
Melting Point	175-177 °C
Solubility	Soluble in water (50 mg/ml), ethanol (~1 mg/ml), DMSO (~13 mg/ml), DMF (~14 mg/ml), and PBS, pH 72 (~10 mg/ml)
Boiling Point	752.16 °C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 MG

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