Pepstatin A, 25 MG

X1036275-1

Pepstatin A is a competitive, reversible aspartic protease inhibitor and inhibits proteases such as pepsin, chymosin, renin, HIV proteases, and cathepsins D and E. It is highly selective and is often used in a mixture with other enzyme inhibitors. In vitro studies have shown pepstatin A is the only aspartic acid inhibitor that exhibits inhibitory effects on HIV proteases. Pepstatin A may also suppress differentiation of osteoclasts by inhibiting phosphorylation of MAP kinase and inhibiting NFATc1 expression. Pepstatin A application in cold inducible RNA-binding protein (CIRP) via CRISPR-Cas9 system 1 . Pepstatin A inhibits lysosomal proteases directly 2 . 1.) http://nar.oxfordjournals.org/content/44/2/761.full.pdf+html 2.) http://www.pnas.org/content/112/31/E4281.full.pdf

DMSO (5 mg/ml) or Methanol (1 mg/ml)

White Solid