BMS-819881

Item no.	HY-12433-50mg
Manufacturer	MedChem Express
CASRN	1197420-05-5
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Glucose Homeostasis Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.78
Citations	[1]Washburn WN, et al. Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate. J Med Chem. 2014 Sep 25;57(18):7509-22.
Smiles	ClC1=CC=C(C2=CC(N=CN(C3=CC(OC)=C(OC[C@H](O)C4CC4)C=C3)C5=O)=C5S2)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Cytochrome P450; MCHR1 (GPR24)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	468.95
Product Description	BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.
Manufacturer - Research Area	Metabolic Disease; Endocrinology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Clinical information	Phase 2
Isoform	CYP3

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