« Back
Home /
L-Ascorbic acid

L-Ascorbic acid

Item no.	HY-B0166-25g
Manufacturer	MedChem Express
CASRN	50-81-7
Amount	25 g
Category	Food Safety Vitamines Inhibitors & Compound Libraries Small Molecules Acid Determination
Type	Inhibitors
Specific against	other
Purity	99.99
Citations	[1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.\|[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.\|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.\|[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372.\|[5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2. ACS Nano. 2025 Mar 18;19(10):10180-10198. Adv Mater. 2024 Dec 26:e2415543. Anim Biotechnol. 2024 Nov;35(1):2404043. Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. Antioxidants (Basel). 2024 May 27;13(6):653. Biochem Biophys Res Commun. 2024 May 14:708:149770. Biol Methods Protoc. 2025 Feb 13;10(1):bpaf012. Biol Pharm Bull. 2025;48(6):895-907. Biomaterials. 2024 Aug 15:313:122756. Biomed Pharmacother. 2022 Sep:153:113558. Bioorg Chem. 2021 Oct:115:105177. Bioorg Chem. 2024 May:146:107261. Bioorg Chem. 2025 Jan 5:155:108133. bioRxiv. 2025 August 25. Biosci Rep. 2019 May 21;39(5):BSR20182137. Bone Res. 2025 Mar 3;13(1):30. Cancer Cell Int. 2024 May 31;24(1):192. Cancer Cell. 2024 Apr 8;42(4):682-700.e12. Cell Biol Toxicol. 2023 Jun;39(3):679-702. Cell Cycle. 2023 Feb;22(4):476-493. Cell Host Microbe. 2024 Dec 12:S1931-3128(24)00444-X. Clin Exp Pharmacol Physiol. 2024 Nov;51(11):e13923. Cytotechnology. 2021 Dec;73(6):787-800. Drug Chem Toxicol. 2024 May;47(3):347-355. Eur J Med Chem. 2022 Mar 5:231:114151. Fitoterapia. 2021 Sep:153:104984. Food Biosci. 2025 Sep 18;73:107628. Food Funct. 2022 May 10;13(9):5089-5101. Free Radic Biol Med. 2020 Feb 1;147:220-230. Front Cell Dev Biol. 2022 Feb 10:10:810327. Genes (Basel). 2024 Sep 13;15(9):1206. Ind Crops Prod. 2025 Oct 18;237:122143. Int J Biol Macromol. 2024 Jan;256(Pt 1):127779. Int J Biol Macromol. 2025 May 15:144179. Int J Mol Sci. 2025 Feb 5;26(3):1334. iScience. 2024 Feb 5;27(3):109111. IUBMB Life. 2024 Oct;76(10):832-844. J Adv Res. 2025 May 10:S2090-1232(25)00309-1. J Agric Food Chem. 2025 Jun 4;73(22):13891-13901. J Biol Chem. 2023 Dec;299(12):105462. J Cell Mol Med. 2020 Apr;24(7):4212-4222. J Cell Physiol. 2024 May;239(5):e31215. J Ethnopharmacol. 2024 Nov 29:340:119128. J Mol Histol. 2024 Aug;55(4):503-512. J Nat Prod. 2022 Jul 22;85(7):1808-1815. J Neuroinflammation. 2025 Sep 24;22(1):211. J Neurosci Res. 2019 Dec;97(12):1689-1705. J Orthop Surg Res. 2025 Apr 15;20(1):379. J Orthop Surg Res. 2025 Nov 14;20(1):997. J Orthop Surg Res. 2025 Oct 29;20(1):943. J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913. J Sex Med. 2018 Feb;15(2):136-147. Mater Today Bio. 2025 Jun 21:33:102009. Mol Biol Rep. 2024 Mar 14;51(1):421. Mol Med Rep. 2019 Dec; 20(6): 4933–4942. Mol Pharmacol. 2025 Sep 28. Nat Immunol. 2023 Feb;24(2):280-294. Nigerian Journal of Scientific Research. 18 (3): 2019. Oxid Med Cell Longev. 2022 Jan 27:2022:7502632. Redox Biol. 2022 Aug;54:102392. Redox Rep. 2024 Dec;29(1):2428147. Res Sq. 2025 Jul 21. Res Sq. 2025 Oct 27. Research Square Print. 2022 Aug. Sci China Life Sci. 2018 Oct;61(10):1151-1167. SSRN. 2025 Jan 14. Environ Toxicol. 2021 Apr;36(4):520-529. FASEB J. 2020 Sep;34(9):11474-11487. Hematol Oncol. 2024 Jul;42(4):e3295. J Afr Ass Physiol Sci. 7(1): 30-37, July 2019. Med Rev (2021). 2024 Jun 14;4(6):531-543. Mil Med Res. 2020 Nov 1;7(1):52. Nat Commun. 2025 Jul 18;16(1):6621.
Smiles	OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	L-Ascorbate,Vitamin C
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Category	Reference compound / Active compounds; API; Natural Products
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	RT, protect from light
Product Description	L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
Manufacturer - Research Area	Cancer; Metabolic Disease; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : ≥ 100 mg/mL
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Clinical information	Launched
Isoform	Microbial Metabolite; T-type calcium channel
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.