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Amifostine thiol dihydrochloride

Amifostine thiol dihydrochloride

Manufacturer	MedChem Express
Category	Inhibitors
Type	Inhibitors
Specific against	other
Amount	100mg
Item no.	HY-103640-100mg
CASRN	14653-77-1
Available
Product Description	Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway.
StorageTemperature	-20°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications	Cancer-programmed cell death
Formula	C5H16Cl2N2S
References	[1].Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4; 278(14):11879-87. \| [2].Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun; 297(3):1067-73. \| [3].Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19(5): 490-496.
MolecularWeight	207.16
Research Area	Cancer
Solubility	H2O : ≥ 100 mg/mL (482.72 mM) \| DMSO : 25 mg/mL (120.68 mM; Need ultrasonic)
Target	MDM-2/p53
Pathway	Apoptosis

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Amount: 100mg

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