Comparison

Amifostine thiol dihydrochloride European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 100mg
Item no. HY-103640-100mg
CASRN 14653-77-1
Available
Product Description
Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway.
StorageTemperature
-20°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Applications
Cancer-programmed cell death
Formula
C5H16Cl2N2S
References
[1].Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4; 278(14):11879-87. | [2].Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun; 297(3):1067-73. | [3].Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19(5): 490-496.
MolecularWeight
207.16
Research Area
Cancer
Solubility
H2O : ≥ 100 mg/mL (482.72 mM) | DMSO : 25 mg/mL (120.68 mM; Need ultrasonic)
Target
MDM-2/p53
Pathway
Apoptosis

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 100mg
Available: Out of stock
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