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Borofalan

Borofalan

Item no.	HY-129812-25mg
Manufacturer	MedChem Express
CASRN	80994-59-8
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.59
Citations	[1]Hirose K, et al. Boron neutron capture therapy using cyclotron-based epithermal neutron source and borofalan (10B) for recurrent or locally advanced head and neck cancer (JHN002): An open-label phase II trial. Radiother Oncol. 2021 Feb;155:182-187. [2]Hirose K, et al. Updated results of a phase II study evaluating accelerator-based boron neutron capture therapy (AB-BNCT) with borofalan (10B)(SPM-011) in recurrent squamous cell carcinoma (R-SCC-HN) and recurrent and locally advanced non-SCC (R/LA-nSCC-HN) of the head and neck[J]. Annals of Oncology, 2019, 30: v460. [3]Sato M, et al. Safety of Boron Neutron Capture Therapy with Borofalan (10B) and Its Efficacy on Recurrent Head and Neck Cancer: Real-World Outcomes from Nationwide Post-Marketing Surveillance[J]. Cancers, 2024, 16(5): 869.
Smiles	OC([C@@H](N)CC1=CC=C(C=C1)[10B](O)O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Isotope-Labeled Compounds
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	208.21
Product Description	Borofalan-10B can be used for Boron neutron capture research (BNCT). Borofalan-10B can be used for the research of recurrent or locally advanced head and neck cancer[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	H2O : 4 mg/mL (ultrasonic; warming; adjust pH to 11 with NaOH; heat to 70°C)
Manufacturer - Pathway	Others
Clinical information	Launched

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HY-129812-25mg-safety-datasheet.pdf