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YO-01027 (GMP)

YO-01027 (GMP)

Item no.	HY-13526G-1ea
Manufacturer	MedChem Express
CASRN	209984-56-5
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Formula	C26H23F2N3O3
Citations	[1]Ichida JK, et al. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug;10(8):632-639. [2]Wu J, et al. Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice. Cell Prolif. 2020 Sep;53(9):e12872. [3]Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74.
Smiles	O=C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C)C1=O)=O)CC4=CC(F)=CC(F)=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Dibenzazepine (GMP), DBZ (GMP)
Shipping condition	Room temperature
Available
Manufacturer - Type	GMP Small Molecules
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Notch; γ-secretase
Shipping Temperature	Room Temperature
Molecular Weight	463.48
Product Description	YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent γ-secretase inhibitor[1][2].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Neuronal Signaling; Stem Cell/Wnt
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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