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(S)-Verapamil (hydrochloride)-d6

(S)-Verapamil (hydrochloride)-d6

Item no.	HY-135336AS1-10mg
Manufacturer	MedChem Express
CASRN	1329611-24-6
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22.\|[3]Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.
Smiles	COC(C=C1CCN(C)CCC[C@@](C#N)(C2=CC(OC)=C(C=C2)OC)C(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1)OC.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	(S)-(-)-Verapamil (hydrochloride)-d6
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Apoptosis; Calcium Channel; Isotope-Labeled Compounds; Leukotriene Receptor
Shipping Temperature	Room temperature
Molecular Weight	497.10
Product Description	(S)-Verapamil-d6 ((S)-(-)-Verapamil-d6) hydrochloride is the deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Clinical information	No Development Reported

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Amount: 10 mg

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