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PF-05221304

PF-05221304

Item no.	HY-137846-10mg
Manufacturer	MedChem Express
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1370448-25-1
Similar products	1370448-25-1
Available
Description	PF-05221304 is an orally bioavailable, liver-directed and dual ACC1 (and ACC2) inhibitor with IC50s of 7.5 nM for rat ACC1, 8.2 nM for rat ACC2, 12.4 nM for human ACC1 and 8.7 nM for human ACC2. PF-05221304 is a substrate for organic anion transport polypeptides. PF-05221304 directly improves a variety of non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) pathogenic factors.
Storage Temperature	Powder -20C 3 years; In solvent -80C 6 months, -20C 1 month
CASNumber	1370448-25-1
MolecularWeight	502.56
Clinical_Information	No Development Reported
Research_Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (198.98 mM; Need ultrasonic)
Target	Acetyl-CoA Carboxylase
Pathway	Metabolic Enzyme/Protease

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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