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Cinrebafusp alfa

Cinrebafusp alfa

Item no.	HY-P99605-1ea
Manufacturer	MedChem Express
CASRN	2218515-90-1
Amount	1 ea
Quantity options	10 mg 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.53
Dry ice	Yes
Citations	[1]Marlon J Hinner, et al. Tumor-Localized Costimulatory T-Cell Engagement by the 4-1BB/HER2 Bispecific Antibody-Anticalin Fusion PRS-343. Clin Cancer Res. 2019 Oct 1;25(19):5878-5889.\|[2]G. Ku, et al. 525O A phase I dose escalation study of PRS-343, a HER2/4-1BB bispecific molecule, in patients with HER2-positive malignancies. ABSTRACT ONLY, VOLUME 31, SUPPLEMENT 4, S462-S463, SEPTEMBER 01, 2020.
Smiles	[Cinrebafusp alfa]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PRS 343
Shipping Condition	Dry ice
Available
Manufacturer - Type	Inhibitory Antibodies
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	EGFR; TNF Receptor
Shipping Temperature	Dry Ice
Storage Conditions	Store at -80°C for 2 years
Molecular Weight	(187.87 kDa)
Product Description	Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research[1][2].
Manufacturer - Research Area	Cancer
Solubility	H2O
Manufacturer - Pathway	Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Isoform	ErbB2/HER2; TNFRSF9/4-1BB/CD137
Clinical information	Phase 1

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HY-P99605-1ea-safety-datasheet.pdf