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Biotin-labeled ODN 2088 (sodium)

Biotin-labeled ODN 2088 (sodium)

Item no.	HY-150738A-1ea
Manufacturer	MedChem Express
Amount	1 ea
Category	Other Assays & Kits
Type	Separation, Purification
Specific against	other
Citations	[1]Duramad O, et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol. 2005 May 1;174(9):5193-200. [2]Römmler F, et al. Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. J Immunol. 2013 Sep 15;191(6):3240-53. [3]Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703. [4]Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS One. 2015 Feb 19;10(2):e0116703.
Smiles	[Biotin-labeled ODN 2088 (sodium)]
ECLASS 10.1	32170301
ECLASS 11.0	32170301
UNSPSC	41104900
Shipping Condition	Room temperature
Available
Manufacturer - Type	Oligonucleotides
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Toll-like Receptor (TLR)
Shipping Temperature	Room temperature
Product Description	Biotin-labeled ODN 2088 (sodium) is a potent TLR3, TLR7 and TLR9 inhibitor. Biotin-labeled ODN 2088 (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in H2O
Manufacturer - Pathway	Immunology/Inflammation
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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