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5 Lipoxygenase (ALOX5) Mouse Monoclonal Antibody [Clone ID: LBI3F1]

5 Lipoxygenase (ALOX5) Mouse Monoclonal Antibody [Clone ID: LBI3F1]

Item no.	LBI-AMM17585VCF
Manufacturer	Leading Biology
Amount	100 ug
Category	Metabolism Cholesterol & Lipid Metabolism Antibodies Enzymes Leukotriene Metabolism
Type	Antibody Monoclonal
Format	Lyophilized
Clone	LBI3F1
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG2a
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	5-LO, 5-LOX, 5LPG, LOG5
Available
Manufacturer - Category	mAbs-V
Manufacturer - Targets	ALOX5
Storage Conditions	Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Field of Research	Arachidonic acid metabolism, Metabolic pathways
Overview	Carrier-free (BSA/glycerol-free) ALOX5 mouse monoclonal antibody, clone LBI3F1
Immunogen	Human recombinant protein fragment corresponding to amino acids 18-364 of human ALOX5(NP_000689) produced in E.coli.
Gene Name	Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 1, mRNA.
Symbol	ALOX5
Function	Druggable Genome
Summary	This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8, 11, 14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7, 9-trans-11, 14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Manufacturer - Format	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Storage Buffer	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Dilution	WB 1:2000, IHC 1:150
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Pathway	Arachidonic acid metabolism, Metabolic pathways

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 1/15/2026

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