Anti-HSF2 Antibody (11105)

Antibody Products>Heat Shock and Stress Protein Antibodies|Products

Next Day 2 - 8°C

Heat shock factor 1 (HSF1) is a heat shock
transcription factor that activates the
transcription of genes encoding products
required for protein folding, processing,
targeting, degradation, and function. Upregulation of expression of heat shock
proteins in response to stress occurs at the
level of transcription through a heat shock
element and a HSF transcription factor.
Amino acid sequences for most HSFs are
highly conserved. A DNA binding domain is
at the N-terminus, hydrophobic repeats
(essential to the formation of active trimers)
are adjacent to this binding domain, and
another short hydrophobic repeat
(necessary for suppression of trimerization)
occurs toward the C-terminus. HSF2 exists
as two isoforms, the alpha form being more
transcriptionally active than the smaller beta
form. Various experiments have suggested
that HSF2 may play roles in differentiation
and development.

PBS, pH 7.4.