Anti-Gonadotropin Releasing Hormone Mouse Monoclonal Antibody - Library Pack (193101) - 4x 100μg

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Gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH), is a 10 amino acid neurohormone produced in the hypothalamus. GnRH stimulates the synthesis and secretion of the two gonadotropins—luteinizing hormone (LH) and follicle stimulating hormone (FSH)—by the anterior pituitary gland. Characteristic of all releasing hormones, and most striking in the case of GnRH, is the phenomenon of pulsatile secretion. Under normal circumstances, GnRH is released in pulses at intervals of about 90 to 120 minutes. Abnormalities in the pulsatile secretion of GnRH result in subnormal fertility and abnormal or absent menstruation. Constant administration of GnRH suppresses gonadotropin secretion, which has therapeutic benefits in certain patients, such as children with precocious puberty and men with prostate cancer.

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