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PEAQX (tetrasodium hydrate)

PEAQX (tetrasodium hydrate)

Item no.	HY-12294A-5mg
Manufacturer	MedChem Express
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.\|[2]Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.\|[3]Qian Xu, et al. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. J Neurol Sci. 2017 May 15;376:166-175. Am J Hypertens. 2021 Apr 15;hpab047.\|Cells. 2023 Apr 22, 12(9), 1212.\|Front Neurosci. 2021; 15: 703044.\|J Clin Invest. 2019 Sep 3;129(9):3864-3876.\|Neuroscience. 2018 Nov 1;391:1-12.
Smiles	BrC1=CC=C([C@H](C)NC(P(O[Na])(O[Na])=O)C2=CC=CC3=C2N=C(O[Na])C(O[Na])=N3)C=C1.[H]O[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NVP-AAM077 (tetrasodium hydrate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Apoptosis; Caspase; iGluR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	560.15
Product Description	PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	H2O: 25.5 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Isoform	NMDA Receptor
Clinical information	No Development Reported

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HY-12294A-5mg-safety-datasheet.pdf