Montelukast (sodium)

Item no.	HY-13315-10mM
Manufacturer	MedChem Express
CASRN	151767-02-1
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 500 mg 50 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.84
Citations	[1]Pu S, et, al. Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury. Front Pharmacol. 2019 Sep 18; 10:1070.\|[2]William RHJ, et, al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med. 2002 Jan 1; 165(1): 108-16.\|[3]Langlois A, et al. Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism. J Allergy Clin Immunol. 2006;118(1):113-119.\|[4]Khan AR, et al. Montelukast in hospitalized patients diagnosed with COVID-19. J Asthma. 2022 Apr;59(4):780-786. Artif Cell Nanomed B. 2019 Dec;47(1):4234-4239.\|Eur J Pharmacol. 2022 May 15;923:174892.\|J Cachexia Sarcopenia Muscle. 2022 Jun 9.\|Patent. US20230404992A1.\|Adv Mater. 2024 Jun;36(24):e2311760.\|Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb 27.\|Patent. US20210309696A1.\|Patent. US20230348536A1.\|SSRN. 2024 Oct 29.
Smiles	ClC1=CC2=C(C=C1)C=CC(/C=C/C3=CC([C@H](SCC4(CC(O[Na])=O)CC4)CCC5=CC=CC=C5C(C)(O)C)=CC=C3)=N2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MK0476
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Leukotriene Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	608.17
Product Description	Montelukast sodium (MK0476) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast sodium decreases eosinophil infiltration into the asthmatic airways. Montelukast sodium can also be used for COVID-19 research[1][2][3][4].
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein
Clinical information	Launched
Isoform	LTD4/CysLT1

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