IWP-2

Item no.	HY-13912-10mM
Manufacturer	MedChem Express
CASRN	686770-61-6
Amount	10 mMx1 mL
Quantity options	100 mg 10 mMx1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Chen B, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.\|[2]Maiti G, et al. The Wingless homolog Wnt5a stimulates phagocytosis but not bacterial killing. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16600-5.\|[3]García-Reyes B, et al. Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε. J Med Chem. 2018 May 10;61(9):4087-4102. ACS Comb Sci. 2019 Dec 9;21(12):805-816.\|Adv Mater. 2021 Oct 10;e2104829.\|Autoimmunity. 2023 Dec;56(1):2182741.\|Biochem Pharmacol. 2019 Nov;169:113608.\|Bioengineering (Basel). 2023 Jun 9, 10(6), 702.\|bioRxiv. 2024 Mar 13.\|Cell Rep Methods. 2024 May 8:100777.\|Clin Sci. 2023 Jan 13;137(1):109-127.\|Dev Cell. 2020 Dec 21;55(6):679-694.e11.\|eNeuro. 2025 Jan 9:ENEURO.0347-24.2024.\|Exp Cell Res. 2022 Nov 11;422(1):113416.\|Exp Ther Med. 2020 Mar;19(3):1701-1710.\|J Appl Polym Sci. 2024 Sep 25.\|J Cell Physiol. 2020 Jul;235(7-8):5811-5822.\|J Inflamm Res. 2024 Nov 19:17:8945-8964.\|Microb Pathog. 2024 Sep 21:106960.\|Neoplasia. 2024 Dec 30:60:101096.\|Patent. US20180263995A1.\|PLoS One. 2024 Jan 5;19(1):e0287206.\|SSRN. 2024 Mar 26.\|Stem Cell Res Ther. 2024 Oct 8;15(1):350.\|Stem Cells Transl Med. 2021 May;10(5):743-755.\|Nat Protoc. 2024 Mar 28.
Smiles	O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	IWP 2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Casein Kinase; Porcupine; Wnt
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	466.60
Product Description	IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMF : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)\|DMSO : 2 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Stem Cell/Wnt
Clinical information	No Development Reported
Isoform	CK1

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