Enzalutamide

Item no.	HY-70002-500mg
Manufacturer	MedChem Express
CASRN	915087-33-1
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 200 mg 2 g 500 mg 50 mg 5 g 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.97
Citations	[1]Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science, 2009, 324 (5928), 787-790.\|[2]Scher HI, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet, 2010, 375(9724), 1437-1446.\|[3]Guerrero J, et al. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 2013 Sep;73(12):1291-305.\|[4]Kim TH, et al. Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats. Arch Pharm Res. 2015 Nov;38(11):2076-82.
Smiles	S=C(N(C(C1(C)C)=O)C2=CC=C(C#N)C(C(F)(F)F)=C2)N1C3=CC(F)=C(C(NC)=O)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MDV3100
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Androgen Receptor; Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	464.44
Product Description	Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 50 mg/mL
Manufacturer - Pathway	Autophagy; Vitamin D Related/Nuclear Receptor
Clinical information	Launched

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HY-70002-500mg-safety-datasheet.pdf