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Ac-DEVD-AMC

Ac-DEVD-AMC

Item no.	HY-P1003-5mg
Manufacturer	MedChem Express
CASRN	169332-61-0
Amount	5 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Cell Biology Cell Status Apoptosis Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.93
Citations	[1]Nobel CS, et al. Disulfiram is a potent inhibitor of proteases of the caspase family. Chem Res Toxicol. 1997 Dec;10(12):1319-24. \|[2]Ochu EE, et al. Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells. J Neurochem. 1998 Jun;70(6):2637-40. \|[3]Yakovlev AA, Gorokhovatsky AY, Onufriev MV, Beletsky IP, Gulyaeva NV. Brain cathepsin B cleaves a caspase substrate. Biochemistry (Mosc). 2008 Mar;73(3):332-6.
Smiles	CC(C1=CC=C(NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O)C=C1O2)=CC2=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	169332-61-0
Shipping Condition	Cool pack
Available
Manufacturer - Type	Dye Reagents
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Fluorescent Dye
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Molecular Weight	675.64
Product Description	Ac-DEVD-AMC is a fluorescent substrate of caspase-3/caspase-7. When treating Ac-DEVD-AMC with cell lysate, Ac-DEVD-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection, with an excitation wavelength of 380 nm and an emission wavelength of 460 nm[1][2][3].
Manufacturer - Research Area	Others
Solubility	H2O: < 0.1 mg/mL
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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HY-P1003-5mg-safety-datasheet.pdf