3-Nitropropionic Acid

Blue Ice

119, 1

Supplied as a light yellow powder.

A cell-permeable, irreversible inactivator (~3mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.

Synonyms:
3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA

CAS Number:
504-88-1

Molecular Formula:
C₃H₅NO₄

Solubility:
DMSO or EtOH

Molecular Weight:
119.1

Storage and Stability:
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.