Lactate Dehydrogenase A Inhibitor, FX11 (LDHA Inhibitor I, LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I)

Blue Ice

352

Supplied as a white to off white solid.

A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8uM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866. Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.

Synonyms:
LDHA Inhibitor I, LDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I

CAS No:
213971-34-7

Molecular Formula:
C22H22O4

Purity:
≥96% (HPLC)

Appearance:
White to off white solid

Solubility:
DMSO

Method for Determining Identity:
Proton NMR Spectroscopic and LC-MS Spectrometric Analysis

Water by CHN (mol):
≤1mol

Carbon:
73.0-76.0%

Hydrogen:
5.5-7.5%

Storage and Stability:
Lyophilized powder may be stored at 4°C. Stable for 6 months after receipt.. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store under inert gas. Light sensitive.