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apoptosis-activator-2

apoptosis-activator-2

Manufacturer	InvivoChem LLC
Category	Food Safety Mycotoxins Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	500mg
Item no.	V0026-500mg
CASRN	79183-19-0
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V0026CAS #:79183-19-0Purity >=98% Description: Apoptosis Activator 2 is a novel and potent small molecule apoptosis activator with IC50 value of about 4uM. Apoptosis Activator 2 is a cell permeable compound that promotes apoptosis by activating caspases in a cytochrome c- and Apaf-1-dependent manner. 20uM Apoptosis Activator 2 increases the fraction of Apaf-1 in the apoptosome when there is 0.15uM cytochrome c. Apoptosis Activator 2 was found to induce the oligomerization of Apaf-1. Through the induction of apoptosis, Apoptosis Activator 2 notably induces caspase-3 activation, PARP cleavage and DNA fragmentation. References: Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7533-8; Neural Dev. 2009 Mar 16; 4:11.
Molecular Weight (MW)	306.14
Formula	C15H9Cl2NO2
CAS No.	79183-19-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 61 mg/mL (199.25 mM)
	Water:< 1 mg/mL (slightly soluble or insoluble)
	Ethanol: < 1 mg/mL
Other info	Synonym: Apoptosis Activator 2; MDK83190; MDK-83190; MDK 83190; AAII; N-(3, 4-dichlorobenzyl) Isatin; Chemical Name: 1-[(3, 4-dichlorophenyl)methyl]-1H-indole-2, 3-dione InChi Key: KGRJPLRFGLMQMV-UHFFFAOYSA-N InChi Code: InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H, 8H2 SMILES Code: O=C1N(CC2=CC=C(Cl)C(Cl)=C2)C3=C(C=CC=C3)C1=O

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Amount: 500mg

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Delivery expected until 7/4/2024