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itacitinib-adipate

itacitinib-adipate

Item no.	V0066-500mg
Manufacturer	InvivoChem LLC
CASRN	1334302-63-4
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0066CAS #:1334302-63-4Purity >=98% Description: Itacitinib adipate, the adipate salt of itacitinib which is also known as INCB39110, is a potent, selective and orally bioavailable inhibitor of JAK1 (Janus-associated kinase 1) with potential antineoplastic activity, currently in Phase II clinical trials for the treatment of myelofibrosis, rheumatoid arthritis and plaque psoriasis. Description: References: Haematologica. 2017 Feb; 102(2):327-335; Expert Opin Ther Pat. 2017 Feb; 27(2):127-143; AACR; Cancer Res. 2015, 75(15 Suppl). References: Related CAS: 1334298-90-6 (free base) 1334302-63-4 (adipate salt)
Molecular Weight (MW)	699.66
Formula	C??H??F?N?O?
CAS No.	1334302-63-4 (adipate salt)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 90 mg/mL
	Water: N/A
	Ethanol: > 90 mg/mL
Chemical Name	2-(3-(4-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile adipate
Synonyms	INCB039110; INCB-039110; INCB 039110; INCB39110; INCB 39110; INCB-39110
SMILES Code	N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1 .O=C(O)CCCCC(O)=O

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Amount: 500mg

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