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Description: A66 is a novel, potent, reversible, ATP-competitive and highly selective p110alpha inhibitor with potential anticancer activity. It has an IC50 of 32 nM for inhibiting p110alpha in a cell-free assay, and showed > 100 fold selectivity for p110alpha over other class-I PI3K isoforms.
References: Biochem J. 2011 Aug 15; 438(1):53-62; EMBO Mol Med. 2013 Apr; 5(4):563-71.
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