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Description: CZC24832 is a novel, potent and highly selective inhibitor of PI3Kgamma (phosphoinostide 3-kinase gamma) with a potential for treatment for inflammatory and autoimmune diseases (e.g. RA). It inhibits PI3Kgamma with an IC50 of 27 nM, showed 10-fold selectivity for PI3Kgamma over PI3Kbeta, and displayed > 100-fold selectivity for PI3Kgamma over PI3Kalpha and PI3Kdelta.
References:Nat Chem Biol. 2012 Apr 29; 8(6):576-82.
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