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laq824-dacinostat

laq824-dacinostat

Item no.	V0280-250mg
Manufacturer	InvivoChem LLC
CASRN	404951-53-7
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0280CAS #:404951-53-7Purity >=98% Description: Dacinostat (formerly LAQ824; NVP-LAQ824) is a novel, potent and hydroxamate-based inhibitor of histone deacetylase (HDAC) with potential anticancer activity. It inhibits HDAC with an IC50 of 32 nM; It shows potent anti-proliferative activity in vitro against various cancer cell lines such as H23 and H460 cell lines. Description: References: Cancer Res. 2004 Jan 15; 64(2):689-95; J Immunol. 2011 Apr 1; 186(7):3986-96. References:
Molecular Weight (MW)	379.46
Formula	C22H25N3O3
CAS No.	404951-53-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 76 mg/mL (200.3 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 30mg/mL
Synonyms	NVP-LAQ824; NVP-LAQ-824; NVP LAQ824; LAQ 824; LAQ824; LAQ-824; Dacinostat Chemical Name: (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide InChi Key: BWDQBBCUWLSASG-MDZDMXLPSA-N InChi Code: InChI=1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10, 15, 23, 26, 28H, 11-14, 16H2, (H, 24, 27)/b10-9+ SMILES Code: O=C(NO)/C=C/C1=CC=C(CN(CCO)CCC2=CNC3=C2C=CC=C3)C=C1

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Amount: 250mg

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Delivery expected until 12/6/2024

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