Levetiracetam (UCB-L 059, SIB-S 1)

Description: Levetiracetam (also known as UCB-L059, SIB-S1) is a potent and selective M2 muscarinic acetylcholine receptors (mAChR) inhibitor and an anticonvulsant medication used to treat epilepsy. Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons.

References: Nature. 2005 May 26; 435(7041):519-22; Br J Pharmacol. 2002 Jul; 136(5):659-72.

UCB 6474,

Chemical Name: (S)-2-(2-oxopyrrolidin-1-yl)butanamide

InChi Key: HPHUVLMMVZITSG-LURJTMIESA-N

InChi Code: InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H, 2-5H2, 1H3, (H2, 9, 12)/t6-/m0/s1

SMILES Code: O=C(N)[CH](CC)N1C(CCC1)=O