PFI-2

Item no.	V0397-25mg
Manufacturer	InvivoChem LLC
CASRN	1627676-59-8
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1627676-59-8
Available
Description	InvivoChem Cat #:V0397CAS #:1627676-59-8Purity >=98% Description: PFI-2 (PFI2) is a novel, potent and selective inhibitor of lysine methyltransferase SETD7 SET domain containing (lysine methyltransferase) 7 with anticancer activity. It inhibits SETD7 with a Ki (app) and IC50 of 0.33 nM and 2 nM, respectively, and shows > 1000-fold selectivity for SETD7 over other methyltransferases and other non-epigenetic targets. In HEK293 cells, (R)-PFI-2 (10 uM) bound to and stabilized SETD7. In Setd7+/+ murine embryonic fibroblasts (MEFs), (R)-PFI-2 increased nuclear localization of Yes-associated protein (YAP) and the expression of YAP target genes Ctgf, Gli2 and Cdc20. Description: References: Proc Natl Acad Sci U S A. 2014 Sep 2; 111(35):12853-8. References: Related CAS #: 1627676-59-8 (free base); 1627607-87-7 (HCl)
Molecular Weight (MW)	499.52
Formula	C23H25F4N3O3S
CAS No.	1627676-59-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 99 mg/mL (198.2 mM)
	Water: 4 mg/mL (8.0 mM)
	Ethanol: 66 mg/mL (132.1 mM)
Other info	Chemical Name: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1, 2, 3, 4-tetrahydroisoquinoline-6-sulfonamide hydrochloride InChi Key: ZADKZNVAJGEFLC-ZMBIFBSDSA-N InChi Code: InChI=1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32, 33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25, 26)27; /h3-5, 10, 12-13, 21, 28-29H, 1-2, 6-9, 11, 14H2; 1H/t21-; /m1./s1 SMILES Code: O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[CH](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.[H]Cl
Synonyms	PFI-2 hydrochloride; PFI 2; PFI2; PFI-2; (R)-PFI-2; (R)-PFI-2 hydrochloride.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 25 mg

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Delivery expected until 9/4/2025

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