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SGC 0946

SGC 0946

Item no.	V0399-50mg
Manufacturer	InvivoChem LLC
CASRN	1561178-17-3
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1561178-17-3
Available
Description	InvivoChem Cat #:V0399CAS #:1561178-17-3Purity >=98% Description: SGC 0946 (SGC-0946; SGC0946) is a potent and selective inhibitor of DOT1L (DOT1 Like Histone Lysine Methyltransferase) with antineoplastic activity. It inhibits DOT1L with an IC50 of 0.3 nM in a cell-free assay. Description: References: Nat Commun. 2012; 3:1288. References:
Molecular Weight (MW)	618.57
Formula	C28H40BrN7O4
CAS No.	1561178-17-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (161.6 mM)
	Water:< 1 mg/mL
	Ethanol: 100 mg/mL (161.6 mM)
Other info	Chemical Name: 1-(3-((((2R, 3S, 4R, 5R)-5-(4-amino-5-bromo-7H-pyrrolo[2, 3-d]pyrimidin-7-yl)-3, 4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-isobutylphenyl)urea InChi Key: UZLAJVZJBSZSJL-VBHAUSMQSA-N InChi Code: InChI=1S/C28H40BrN7O4/c1-16(2)12-18-6-8-19(9-7-18)34-28(39)31-10-5-11-35(17(3)4)14-21-23(37)24(38)27(40-21)36-13-20(29)22-25(30)32-15-33-26(22)36/h6-9, 13, 15-17, 21, 23-24, 27, 37-38H, 5, 10-12, 14H2, 1-4H3, (H2, 30, 32, 33)(H2, 31, 34, 39)/t21-, 23-, 24-, 27-/m1/s1 SMILES Code: O=C(NC1=CC=C(CC(C)C)C=C1)NCCCN(C[CH]2O[CH](N3C=C(Br)C4=C(N)N=CN=C43)[CH](O)[CH]2O)C(C)C
Synonyms	SGC 0946; SGC0946; SGC-0946

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Amount: 50 mg

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Delivery expected until 11/6/2025

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