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CX-6258 HCl

CX-6258 HCl

Item no.	V0443-5mg
Manufacturer	InvivoChem LLC
CASRN	1353859-00-3
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1353859-00-3
Available
Description	InvivoChem Cat #:V0443CAS #:1353859-00-3Purity >=98% Description: CX-6258 HCl(known also as CX-6258 hydrochloride) is a novel, highly potent and orally bioactive pan-Pim kinase inhibitor with potential anticancer activity. It inhibits Pim1, Pim2, and Pim3 with IC50s of 5 nM, 25 nM and 16 nM, respectively. At CX-6258 showed robust antiproliferative potencies against all cell lines tested derived from human solid tumors and hematological malignancies. In mechanistic cellular assays with MV-4-11 human AML cells, caused dose-dependent inhibition of the phosphorylation of 2 pro-survival proteins, Bad and 4E-BP1, at the Pim kinase specific sites S112 and S65 and T37/46, respectively. Description: References: ACS Med. Chem. Lett., 2012, 3 (2), pp 135–139. References: Related CAS #: 1202916-90-2 (free base); 1353858-99-7 (hydrochloride hydrate)
Molecular Weight (MW)	498.40
Formula	C26H24ClN3O3.HCl
CAS No.	1353859-00-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 89 mg/mL (178.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1, 4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1, 3-dihydro-2H-indol-2-one hydrochloride InChi Key: YYIMMVXTWBIEAG-YHLMHSEJSA-N InChi Code: InChI=1S/C26H24ClN3O3.ClH/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31; /h2, 4-9, 14-16H, 3, 10-13H2, 1H3, (H, 28, 31); 1H/b22-16+; SMILES Code: O=C1NC2=C(C=C(Cl)C=C2)/C1=C\C3=CC=C(C4=CC=CC(C(N5CCN(C)CCC5)=O)=C4)O3.[H]Cl
Synonyms	CX 6258 HCl; CX6258 HCl; CX-6258 HCl; CX 6258 Hydrochloride; CX6258 Hydrochloride; CX-6258 Hydrochloride;

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Amount: 5 mg

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Delivery expected until 9/4/2025

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